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Conclusion Multidrug resistance to chemotherapy drugs is one of the main obstacles in human cancer chemotherapy and has prompted intense research into discovering novel and innovative mechanisms that can overcome this barrier

Antioxidant molecules (AOH) present in the sample which are able to transfer a hydrogen atom to the FORD chromogen radical cation, reduce it, quenching the color and producing a discoloration of the solution which is proportional to their concentration in the sample

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740,741 Glutamate transporter modulator ceftriaxone or N-acetylcysteine stabilize the levels of xCT and reduce infarct volume and neurological deficits in rats within 24 h after stroke

Acknowledgements We would like to thank Seung-Jae Lee (Korea Advanced Institute of Science and Technology) and Alex Mendenhall (University of Washington, USA) for useful discussion, Fangjia Zhao for assistance with transmission electron microscopy, Yimu Fan, Wanlin Sun, and Yihan Wu for other minor research contributions, and Liesbeth Temmerman (Leuven University, Belgium) for providing strains